The Orexin-1 Receptor Antagonist SB-334867 Reduces Alcohol Relapse Drinking, but not Alcohol-Seeking, in Alcohol-Preferring (P) Rats
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چکیده
منابع مشابه
Nicotine modulates alcohol-seeking and relapse by alcohol-preferring (P) rats in a time-dependent manner.
BACKGROUND Alcohol is frequently co-abused with smoking. In humans, nicotine use can increase alcohol craving and consumption. The objectives of the current study were to assess the acute effects of nicotine on alcohol seeking and relapse at 2 different time points. METHODS Adult female alcohol-preferring (P) rats were trained in 2-lever operant chambers to self-administer 15% ethanol (EtOH) ...
متن کاملCB1 Receptors Regulate Alcohol-Seeking Behavior and Alcohol Self-administration of Female Alcohol-Preferring (P) Rats
Rationale—The endogenous cannabinoid (CB) system mediates a number of behaviors associated with drug-seeking and drug self-administration. In this study the effects of CB1 receptor manipulations on operant ethanol (EtOH) responding during EtOH-seeking, EtOHrelapse as well as on-going EtOH self-administration were determined. Methods—Alcohol-preferring (P) rats were trained in 2-lever operant ch...
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A substituted aryl amide derivative of 6-naltrexamine—17-cyclopropylmethyl-3,14b-dihydroxy-4,5a-epoxy-6b-[(49-trimethylfluoro) benzamido]morphinan-hydrochloride—(compound 5), previously shown to be a potent k-opioid receptor antagonist, was used to characterize the physicochemical properties and efficacy to decrease alcohol self-administration in alcohol-preferring rats (P-rats) and binge-like ...
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A substituted aryl amide derivative of 6-naltrexamine--17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-trimethylfluoro)benzamido]morphinan-hydrochloride--(compound 5), previously shown to be a potent κ-opioid receptor antagonist, was used to characterize the physicochemical properties and efficacy to decrease alcohol self-administration in alcohol-preferring rats (P-rats) and binge-like...
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Subclinical levels of polysubstance use are a prevalent and understudied phenomenon. Alcohol is a substance commonly co-used with other substances of other drug classes. These studies sought to determine the consumption effects of combining alcohol drinking and methamphetamine (MA) self-administration. Male alcohol-preferring P rats had continuous access to a two-bottle alcohol drinking procedu...
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ژورنال
عنوان ژورنال: Journal of Addiction Medicine
سال: 2010
ISSN: 1932-0620
DOI: 10.1097/adm.0b013e3181bd893f